Unveiling myeloid transformation: T‐LGLL with eosinophilia masking myeloid‐associated STAT5B mutation culminating in AML.

This article discusses a case study of a 67-year-old woman who initially presented with T-cell large granular lymphocytic leukemia (T-LGLL) with eosinophilia. However, as the disease progressed, it transformed into acute myeloid leukemia (AML) originating from mutated myeloid cells. The study explores the clonal relationships and evolution of different cell populations and highlights the role of the STAT5B mutation in the development of myeloid neoplasms. The research suggests that STAT5B alone can induce myeloid leukemia and that the same mutation in different cell lineages can lead to diverse types of neoplasms. Further research is needed to understand the pathogenesis of STAT5B-mutated neoplasms and develop specific inhibitors. [Extracted from the article]