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KOtBu Mediated Alcohol Dehydrogenation Strategy: Synthesis of 2‐Aryl Quinazolinones.
- Source :
-
ChemistrySelect . 3/18/2024, Vol. 9 Issue 11, p1-7. 7p. - Publication Year :
- 2024
-
Abstract
- Herein we report an atom‐economical, transition metal‐free method for synthesizing 2‐aryl quinazolinones through a cascade annulation of 2‐amino benzamide and benzyl alcohol. The reaction proceeds via KOtBu‐mediated acceptorless alcohol dehydrogenation pathways. The procedure tolerates a wide variety of functional groups and provides a convenient method for the synthesis of 2‐aryl quinazolinones. Mechanistic insights by experiments and DFT calculations lead to unveil the reaction mechanism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23656549
- Volume :
- 9
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- ChemistrySelect
- Publication Type :
- Academic Journal
- Accession number :
- 176104641
- Full Text :
- https://doi.org/10.1002/slct.202400468