维生素 D 滴剂联合布地奈德气雾剂治疗儿童哮喘的疗效 及对患儿肺功能、免疫功能和炎症因子的影响.

To explore the efficacy of vitamin D drops combined with budesonide aerosol in the treatment of children with asthma and its effects on lung function, immune function and inflammatory factors. 120 children with asthma admitted to our hospital from August 2019 to December 2022 were randomly divided into observation group and control group, 60 cases in each group. The control group was treated with budesonide aerosol; on the basis of the control group, the observation group was treated with vitamin D drops. The clinical efficacy and clinical symptoms, lung function [forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF), PEF diurnal variation rate], immune function [regulatory T cells (Treg), helper T cells 2 (Th2), Th17] and inflammatory factors [tumor necrosis factor-琢 (TNF-琢), interleukin-6 (IL-6), IL-8] levels before and after treatment were compared between the two groups. The total effective rate of the observation group was higher comparing with the control group (91.67% vs 73.33%, P<0.05). Compared with the control group, the scores of daytime symptoms and nighttime symptoms in the observation group were lower, and the C-ACT score was higher (P<0.05). Compared with the control group, the percentage of FEV1, PEF and Treg in the observation group was higher, and the diurnal variation rate of PEF, the percentage of Th2 and Th17 were lower (P<0.05). After treatment, the percentages of Treg, Th2 and Th17 in the observation group were lower comparing with the control group (P<0.05). The levels of serum TNF-琢, IL-6 and IL-8 in the observation group were significantly lower comparing with the control group (P<0.05). Vitamin D drops combined with budesonide aerosol is effective in the treatment of children with asthma, which can significantly improve the clinical symptoms and lung function, immune function and reduce the level of inflammatory factors. [ABSTRACT FROM AUTHOR]