消癥止痛汤联合耳穴压豆对气滞血瘀型子宫内膜异位症痛经患者 炎症因子和 PGE2、PGF2α 的影响.

To observe the effect of Xiaozheng zhitong decoction combined with auricular point pressing beans on inflammatory factors and prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α) in patients with endometriosis(EMT) dysmenorrhea of qi stagnation and blood stasis type. 98 EMT dysmenorrhea patients who were admitted to Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine from March 2021 to December 2022 were selected as research objects. Patients were divided into control group（conventional western medicine treatment, n=49）and study group （xiaozheng zhitong decoction combined with auricular point pressing beans on the basis of control group, n=49）by random number table method. The efficacy, pain score [pain visual analogue scale (VAS), COX dysmenorrhea symptom score], chinese medicine syndrome scores, inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8)] and PGE2 and PGF2α levels were compared between two groups. The total clinical effective rate in study group was higher than that in control group(P<0.05). 3 courses after treatment, the VAS, COX dysmenorrhea symptom score and total chinese medicine syndrome scores in study group were lower than those in control group (P<0.05). 3 courses after treatment, the levels of IL-6, TNF-α and IL-8 in study group were lower than those in control group (P<0.05). 3 courses after treatment, PGE2 in study group was higher than that in control group, and PGF2α was lower than that in control group (P<0.05). Xiaozheng zhitong decoction combine with auricular point pressing beans in the treatment of EMT dysmenorrhea patients with qi stagnation and blood stasis type can effectively improve dysmenorrhea symptoms, reduce TCM syndrome scores, and regulate serum inflammatory factors and PGE2 and PGF2α levels. [ABSTRACT FROM AUTHOR]