麻杏石甘汤对风热闭肺证肺炎支原体肺炎患儿血清 TLR2、TLR4 和 Th1/Th2 免疫平衡的影响.

To explore the effect of Maxing Shigan decoction on serum Toll like receptor (TLR) 2, TLR4, and helper T cell (Th) 1/Th2 immune balance in children with mycoplasma pneumoniae pneumonia (MPP) of wind heat closed lung syndrome. 100 children with MPP who were admitted to Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine from January 2021 to January 2023 were divided into combined group (treated with conventional western medicine combined with Maxing Shigan decoction, 50 cases) and control group (treated with conventional western medicine, 50 cases) according to the random number table method. The changes in traditional Chinese medicine syndrome scores, tidal breathing and lung function indicators, TLR2, TLR4, and Th1/Th2 immune balance indicators between two groups were compared. 14 d after treatment, the scores of fever and aversion to wind, slight sweating, cough, thirsty and eager to drink, tachypnea, phlegm thick and yellow in color, pharyngeal redness in combined group were lower than those in control group (P<0.05). 14 d after treatment, the tidal volume (TV), inspiratory time to expiratory time ratio(I/E), and the expiratory volume at peak tidal expiratory flow and total expiratory volume ratio (VPEF/VE) in combined group were higher than those in control group, and respiratory rate(RR) was lower than that in control group (P<0.05). 14 d after treatment, the TLR2 and TLR4 in combined group were lower than those in control group (P<0.05). 14 d after treatment, the interferon γ (IFN-γ) and IFN-γ/interleukin-4 (IL-4) in combined group were lower than those in control group, and IL-4 was higher than that in control group (P<0.05). Maxing Shigan decoction in the treatment in children with MPP of wind heat closed lung syndrome, which can promote the improvement of clinical symptoms, which can also improve lung function and immune function in children at the same time, regulate the serum TLR2, TLR4 levels. [ABSTRACT FROM AUTHOR]