ATTENUATION OF HAEMODYNAMIC RESPONSES FOR LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION-A COMPARATIVE STUDY BETWEEN LIGNOCAINE ORAL VISCOUS 2% AND ORAL LIGNOCAINE SPRAY 10 % PRIOR TO GENERAL ANAESTHESIA.

Background: To compare efficacy between oral lignocaine viscous 2% and oral lignocaine spray 10% in attenuating the hemodynamic response for laryngoscopy & endotracheal intubation prior to general anaesthesia. Materials and Methods: This study was carried out in 60 patients belonging to ASA I& II, aged between 20 to50 years undergoing elective surgeries. The study will be conducted for a period of 1year in Department of Anaesthesia in Kurnool Medical College, Kurnool. Patients who had hypersensitivity to study drug, patients with severe renal, hepatic, respiratory, cardiac disease, neurological, psychiatric disorders, Difficult Airway-Cormack & Lehane grade 3 and 4 were excluded from the study. Divided in to two groups. Group V receives 10ml of 2% or a lignocaine viscous gargle for 5 minutes prior to induction. Group S receives five puffs of oral lignocaine spray 10% prior to induction. The values for HR, SBP, DBP, and MAP, SPO2 were obtained baseline, after induction, immediately after intubation and 1,3,5 and10 minutes after intubation and compared among the groups. Results: In the current study, after induction the mean HEART RATE starts increasing in group S and in group V mean heart rates tart decreasing after induction and slightly raised after immediately after intubation and gradually decreasing till 10 min after intubation. In group S immediately after intubation highest mean heart rate was observed, and start decreasing at 1 minute, 3 minute, 5minute and 10 minute after intubation but not reached baseline level, the mean heart rate between two groups from after induction to 10 minutes after intubation was significant. (p<0.05). In group S mean SBP start increasing immediately after intubation and gradually start decreasing from 1 minute after intubation to 10 minutes after intubation. The mean SBP between two groups from 1 minute after induction to 10 minutes after intubation was significant. (p<0.05). In group V mean DBP start decreasing immediately after intubation and slightly increased immediately after intubation and gradually decreasing till 10 min after intubation. The mean DBP between two groups from after induction to 10 minutes after intubation was significant. (p<0.05). The mean MAP starts increasing in group S till immediately after intubation and gradually start decreasing from 1 minute after intubation to 10 minutes after intubation but reached baseline level at 3minutes.However, in group V mean MAP start decreasing immediately after intubation and slightly increased immediately after intubation and gradually decreasing till 10 min after intubation. The mean MAP between two groups from after induction to 10 minutes after intubation was significant. (p<0.05). After induction the mean SPO2 starts increasing in both groups and reached to 100% in both groups. Conclusion: The study concluded that oral lignocaine viscous 2% was more effective in blunting the haemodynamic response to laryngoscopy and endotracheal intubation than lignocaine spray 10% No significant adverse events occurred during the study. [ABSTRACT FROM AUTHOR]