Serendipitous Synthesis of 5-Hydroxyuridine from 2′,3′- O -Isopropylidene N 4-Acetylcytidine by Hypervalent Iodine(III)-Mediated Reaction.

This article discusses the synthesis of 5-Hydroxyuridine (5-OHU) and its formation in bacterial tRNA. The authors explore the reaction mechanism and the impact of different parameters on the yield of the desired compounds. They also discuss the conformation of nucleosides, specifically focusing on the sugar geometry and its influence on the overall structure. The study utilizes various techniques to analyze the sugar conformation and its impact on the nucleoside structure. Overall, this research provides insights into the synthesis and properties of 5-hydroxuridine, an important RNA lesion. [Extracted from the article]