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Progress in Lewis-Acid-Templated Diels–Alder Reactions.
- Source :
-
Molecules . Mar2024, Vol. 29 Issue 5, p1187. 23p. - Publication Year :
- 2024
-
Abstract
- The synthesis of natural products with complicated architectures often requires the use of segments with functional groups that can be structurally transformed with the desired stereogenic centers. Bicyclic -lactones have great potential as a suitable segment for natural product synthesis. However, the stereoselective construction of such functionalized bicyclic -lactones is not as straightforward as one might expect. The template-mediated Diels–Alder reaction is one of the most powerful and versatile methods for providing bicyclic -lactones with high regioselectivity and stereoselectivity. In this reaction, the diene is linked to the dienophile by a temporary tether, allowing the reaction to proceed efficiently, yielding a product that can be used for natural product synthesis. This review describes some important instances of the template-mediated Diels–Alder reaction and its application to the synthesis of biologically active compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIELS-Alder reaction
*NATURAL products
*BIOACTIVE compounds
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 29
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 175992264
- Full Text :
- https://doi.org/10.3390/molecules29051187