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Prevalence and prognosis of fulminant type 1 diabetes mellitus in The Middle East: a comparative analysis in a 5-year nationwide cohort.
- Source :
-
BMC Endocrine Disorders . 3/11/2024, Vol. 24 Issue 1, p1-7. 7p. - Publication Year :
- 2024
-
Abstract
- Purpose: To analyze the prevalence and progression of fulminant type 1 diabetes (FT1D) in Qatar. Methods: This retrospective study analyzed consecutive index- diabetic ketoacidosis (DKA) admissions (2015–2020) among patients with new-onset T1D (NT1D) in Qatar. Results: Of the 242 patients, 2.5% fulfilled the FT1D diagnostic criteria. FT1D patients were younger (median-age 4-years vs.15-years in classic-T1D). Gender distribution in FT1D was equal, whereas the classic-T1D group showed a female predominance at 57.6% (n = 136). FT1D patients had a mean C-peptide of 0.11 ± 0.09 ng/ml, compared to 0.53 ± 0.45 ng/ml in classic-T1D. FT1D patients had a median length of stay (LOS) of 1 day (1-2.2) and a DKA duration of 11.25 h (11–15). The median (length of stay) LOS and DKA duration in classic-T1D patients were 2.5 days (1-3.9) and 15.4 h (11–23), respectively. The FT1D subset primarily consisted of moderate (83.3%) and severe 916.7%) DKA, whereas classic T1D had 25.4% mild, 60.6% moderate, and 14% severe DKA cases. FT1D was associated with a higher median white cell count (22.3 × 103/uL) at admission compared to classic T1D (10.6 × 103/uL). ICU admission was needed for 66.6% of FT1D patients, compared to 38.1% of classic-T1D patients. None of the patients in the FT1D group had mortality, while two died in the classic-T1D group. Conclusion: This is the first study establishing the existence of FT1D in ME, which presented distinctively from classic-T1D, exhibiting earlier age onset and higher critical care requirements. However, the clinical outcomes in patients with FT1D seem similar to classic T1D. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYPE 1 diabetes
*LEUKOCYTE count
*MORTALITY
*RESEARCH funding
*DISEASE duration
*SEX distribution
*HOSPITAL care
*RETROSPECTIVE studies
*DESCRIPTIVE statistics
*DIABETIC acidosis
*C-peptide
*SOUTH Asians
*AGE factors in disease
*ARABS
*INTENSIVE care units
*DATA analysis software
*COMPARATIVE studies
*LENGTH of stay in hospitals
*DISEASE progression
*MIDDLE Easterners
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 24
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 175966362
- Full Text :
- https://doi.org/10.1186/s12902-024-01559-8