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免疫组库测序在实体器官移植中的应用.

Authors :
梁厉飞
陈婷婷
杨橙
Source :
Organ Transplantation / Qi Guan Yi Zhi. Mar2024, Vol. 15 Issue 2, p207-213. 7p.
Publication Year :
2024

Abstract

Immune repertoire is defined as the sum of T cells and B cells, which possesses high diversity and enables immune system to respond to various antigen stimuli. With the development of sequencing technique, immune repertoire sequencing can be utilized to deeply understand the changes of lymphocyte clones when rejection occurs at the gene level, and also provide the possibility for the emergence of novel non-invasive diagnostic techniques based on immune repertoire sequencing. In recent years, more and more attempts have been made to apply immune repertoire sequencing in solid organ transplantation, especially in the fields of kidney transplantation, liver transplantation, heart transplantation and post-transplantation infection. In this article, research progresses on the application of immune repertoire sequencing in these fields were reviewed, and current status of immune repertoire sequencing in organ transplantation and its potential as a novel technique for early non-invasive diagnosis of rejection were summarized, aiming to provide reference for subsequent development and clinical application of this technique. [ABSTRACT FROM AUTHOR]

Details

Language :
Chinese
ISSN :
16747445
Volume :
15
Issue :
2
Database :
Academic Search Index
Journal :
Organ Transplantation / Qi Guan Yi Zhi
Publication Type :
Academic Journal
Accession number :
175949617
Full Text :
https://doi.org/10.3969/j.issn.1674-7445.2023192