Selective and Low-cost Potentiometric Sensors to Determine Fexofenadine and Rupatadine in Pharmaceuticals Using Sodium Tetraphenyl Boron as an Ion-exchanger.

In this study, we designed two simple, selective and cost-effective solid-state ion-selective sensors using a polyvinylchloride matrix to detect fexofenadine hydrochloride (FFH) and rupatadine fumarate (RTF) in pharmaceuticals. These sensors utilize the sodium tetraphenyl boron (NaTPB) for ion exchange and β-cyclodextrin for ionophore properties. The FFH sensor shows a linear response within the range of 5 x 10-4 to 2.5 x 10-3 M of FFH at pH levels ranging between 2.5 and 6, exhibiting a Nernstian slope of 56.92 mV decade-1. Similarly, the RTF sensor demonstrates a linear response between 8 x 10-5 and 2.5 x 10-3 M of RTF within the pH range of 2.8-6.4, with a Nernstian slope of 20 mV decade-1. Detection and quantification limits of FFH were found to be 2.5 x 10-4 and 4.5 x 10-4 M, and that of RTF were 2.0 x 10-5 and 6.1 x 10-5 M, respectively. The sensors exhibited excellent selectivity, as indicated by mean percentage recoveries of 100.7 and 99.87 for FFH and RTF, respectively, with a low relative standard deviation (RSD) of less than 2.5%. [ABSTRACT FROM AUTHOR]