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Polymicrobial bloodstream infections per se do not increase mortality compared to monomicrobial bloodstream infections in sepsis patients: a Korean nationwide sepsis cohort study.

Authors :
Lee, Su Yeon
Park, Mi Hyeon
Oh, Dong Kyu
Lim, Chae-Man
Hong, Sang-Bum
Suh, Gee Young
Jeon, Kyeongman
Ko, Ryoung-Eun
Cho, Young-Jae
Lee, Yeon Joo
Lim, Sung Yoon
Park, Sunghoon
Heo, Jeongwon
Lee, Jae-myeong
Kim, Kyung Chan
Chang, Youjin
Lee, Sang-Min
Hong, Suk-Kyung
Cho, Woo Hyun
Kwak, Sang Hyun
Source :
BMC Infectious Diseases. 3/5/2024, Vol. 24 Issue 1, p1-10. 10p.
Publication Year :
2024

Abstract

Background: There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate outcomes of polymicrobial bloodstream infections compared to monomicrobial bloodstream infections. Methods: This study used data from the Korean Sepsis Alliance Registry, a nationwide database of prospective observational sepsis cohort. Adult sepsis patients with bloodstream infections from September 2019 to December 2021 at 20 tertiary or university-affiliated hospitals in South Korea were analyzed. Results: Among the 3,823 patients with bloodstream infections, 429 of them (11.2%) had polymicrobial bloodstream infections. The crude hospital mortality of patients with sepsis with polymicrobial bloodstream infection and monomicrobial bloodstream infection was 35.7% and 30.1%, respectively (p = 0.021). However, polymicrobial bloodstream infections were not associated with hospital mortality in the proportional hazard analysis (HR 1.15 [0.97–1.36], p = 0.11). The inappropriate use of antibiotics was associated with increased mortality (HR 1.37 [1.19–1.57], p < 0.001), and source control was associated with decreased mortality (HR 0.51 [0.42–0.62], p < 0.001). Conclusions: Polymicrobial bloodstream infections per se were not associated with hospital mortality in patients with sepsis as compared to monomicrobial bloodstream infections. The appropriate use of antibiotics and source control were associated with decreased mortality in bloodstream infections regardless of the number of microbial pathogens. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712334
Volume :
24
Issue :
1
Database :
Academic Search Index
Journal :
BMC Infectious Diseases
Publication Type :
Academic Journal
Accession number :
175933389
Full Text :
https://doi.org/10.1186/s12879-024-09130-5