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Circ_0011385 increases cisplatin resistance in breast cancer via miR-615-5p suppression.
- Source :
-
Tropical Journal of Pharmaceutical Research . Feb2024, Vol. 23 Issue 2, p243-249. 7p. - Publication Year :
- 2024
-
Abstract
- Purpose: Circular RNAs (circRNAs) participate in chemo-resistance among different cancers, containing breast cancer (BC). Herein, this project aimed to investigate the role of circ_0011385 on cisplatin (DDP) resistance in BC cells. Methods: circ_0011385 and microRNA (miR)-615-5p content in DDP-resistant BC cells and their parent cells (MCF-7) was calculated by RT-qPCR. CCK-8 assessed inhibition rate, and further to calculate half inhibitory concentration (IC50). Clone formation and flow cytometry experiments detected clone numbers and apoptosis rate. Dual-luciferase reporter system validated targeting between circ_0011385 and miR-615-5p. Results: circ_0011385 was upregulated, whereas miR-615-5p was decreased in MCF-7/DDP cells. Silencing circ_0011385 or miR-615-5p overexpression enhanced BC cell sensitivity to DDP, repress proliferation, and expedite apoptosis rate. Circ_0011385 directly targeted miR-615-5p. CONCLUSION: Silencing circ_0011385 increases DDP sensitivity by targeting and up-regulating miR-615-5p expression in MCF-7/DDP. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CISPLATIN
*BREAST cancer
*BREAST
*CIRCULAR RNA
*FLOW cytometry
*MICRORNA
Subjects
Details
- Language :
- English
- ISSN :
- 15965996
- Volume :
- 23
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Tropical Journal of Pharmaceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 175926757
- Full Text :
- https://doi.org/10.4314/tjpr.v23i2.2