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Current principles for the establishment of the virological "cutoff points" in transfusion science and medicine: A short concise overview.
- Source :
-
Transfusion & Apheresis Science . Feb2024, Vol. 63 Issue 1, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Establishing the virological cutoff point, during epidemics, such as the COVID-19 Pandemic, is crucially important as inadequate standardization and the false qualitative results, have enormous clinical and economic consequences when screening for SARS-CoV-2. Moreover, a cutoff point is a crucial step in ensuring a minimal risk of clinical misclassification. Therefore complying with such statutory requirements is an essential part of obligatory good laboratory and clinical practices. In this concise report, we propose a novel methodology for establishing cutoff points for all samples exhibiting detectable levels of the measured parameter, even those from the disease-free group. Based on target specificity and sensitivity levels of 100 % and 95 %, a value of 1209 A is identified as the "best cutoff". In fact, the ROC decision matrixes play a crucial role in determining optimal cutoff points. The most effective discriminators are those that meet specified accuracy criteria. The selection process is influenced by finding the right clinical sensitivity/specificity trade-off. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14730502
- Volume :
- 63
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Transfusion & Apheresis Science
- Publication Type :
- Academic Journal
- Accession number :
- 175874206
- Full Text :
- https://doi.org/10.1016/j.transci.2024.103875