RNAkines are secreted messengers shaping health and disease.

A new nomenclature 'RNAkine' is proposed to designate extracellular noncoding RNA in light of its tightly regulated secretion, signalling properties, and significance in physiology and diseases. RNAkines are dynamically secreted in response to specific stimuli, ensuring that they are released to function contextually. RNAkines facilitate intercellular communication among multiple organs, orchestrating whole-body homeostasis. RNAkines induced by pathological conditions promote disease development through signalling to both local tissue and distant organs. Extracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the pathogenesis of various diseases. Given the unique aspects of extracellular ncRNAs, here we propose the term 'RNAkine' to describe these recently identified secreted factors. We explore their roles as intercellular modulators, particularly in their ability to regulate metabolism and influence tumorigenesis, highlighting their definition and importance as a distinct class of secreted factors. [ABSTRACT FROM AUTHOR]