Potential Therapeutic Effect of Platelet Rich Plasma in Acne Vulgaris.

BACKGROUND: Acne vulgaris is a worldwide chronic inflammatory dermatological disorder of pilosebaceous unit that adversely affects patients’ quality of life, so safe and effective treatment options are needed. Platelet rich plasma is an autologous highly concentrated platelets in a little amount of plasma. Various growth factors are released after platelet activation that have significant role in angiogenesis, inflammation and wound healing. AIM: to assess the efficacy and safety of platelet rich plasma injection in management of acne vulgaris. METHODS: Thirty patients with acne vulgaris of different severity and duration received four sessions of platelet rich plasma that injected intradermal, one session every two weeks for 8 weeks. RESULTS: The obtained results showed a statistically significant decrease in the total lesion count (P<0.05) and high statistically significant decrease in acne severity index (P<0.01) from baseline. Also, high statistically significant decrease was observed in pustules count (P<0.01) after treatment. Mild side effects were detected in the form of mild to moderate pain, erythema and edema immediately after treatment with Intradermal platelet rich plasma injection. CONCLUSIONS: Intradermal Platelet Rich Plasma injection is promising and effective treatment option for acne vulgaris with tolerable side effects. [ABSTRACT FROM AUTHOR]