急性脑梗死合并脑白质疏松症患者血清 CP、MBP、MCP-1 与病情严重程度和预后的关系.

Objective: To explore the relationship between serum C peptide (CP), myelin basic protein (MBP), monocyte chemotactic protein-1 (MCP-1) levels and disease severity and prognosis in patients with acute cerebral infarction (ACI) combine with leukoaraiosis (LA). Methods: 117 patients with ACI combine with LA admitted to Suqian Hospital of Nanjing Gulou Hospital Group from March 2021 to March 2023 were selected as observation group, patients were divided into severe group (39 cases), moderate group (40 cases), and mild group (38 cases) according to the severity of LA. 120 healthy individuals who underwent physical examinations during the same period were selected as control group. Detected serum levels of CP, MBP, and MCP-1. Follow up patients with ACI combine with LA 6 months. The influencing factors of poor prognosis in patients with ACI combined with LA were analyzed by multivariate Logistic regression. The predictive value of serum CP, MBP and MCP-1 in ACI patients with LA was analyzed by receiver operating characteristic(ROC) curve. Results: Compared with control group, observation group had higher levels of MBP and MCP-1, lower levels of CP (P<0.05). Serum CP in severe group was lower than that in mild and moderate groups, and the levels of MBP and MCP-1 were higher than those in mild and moderate groups; Serum CP in moderate group was lower than that in mild group, and the levels of MBP and MCP-1 were higher than those in mild group (all P<0.05). Compared with good prognosis group, poor prognosis group had lower CP and higher MBP and MCP-1 (P<0.05). Multivariate logistic regression analysis showed that elevated NIHSS score, MBP, and MCP-1 were independent risk factors for poor prognosis in patients with ACI combine with LA, and elevated CP was a protective factor (P<0.05). ROC analysis results showed that the area under the curve (AUC) of CP, MBP, and MCP-1 combined predicting poor prognosis in patients with ACI combine with LA was 0.916, significantly higher than CP, MBP and MCP-1 alone. Conclusion: The serum CP of patients with ACI combine with LA is lower than that in healthy group, and the serum MBP and MCP-1 levels are higher than those in healthy group, and there is a close relationship between CP, MBP, and MCP-1 and the severity of the patient's condition. The combined detection of serum CP, MBP, and MCP-1 has high predictive value for the prognosis of patients with ACI combine with LA. [ABSTRACT FROM AUTHOR]