MTA、iRoot BP Plus 及氢氧化钙在年轻恒牙活髓切断术中 临床疗效的比较分析.

Objective: To investigate the clinical efficacy of three materials, mineral trioxide agglomerate（MTA), i Root BP Plus（i RooT), and calcium hydroxide（Ca(OH)2), in the live pulpotomy of young permanent teeth. Methods: Sixty patients（60 affected teeth）requiring vivipectomy of young permanent teeth were randomly divided into three groups according to the materials used: the MTA group, the i RooT group and the Ca(OH)2 group, with 20 patients（20 affected teeth） in each group. The success rate of the procedure, the incidence of dentin bridge formation and tooth discoloration, root canal wall thickness, tooth function and aesthetics, and serum matrix metalloproteinase-3（MMP-3） and interleukin-8（IL-8） levels were compared between the three groups at 3 and 6 months after surgery. Results:（1） The clinical treatment success rate was different among the three groups at 6 months postoperatively only（P＜0. 05); （2） The postoperative dentin bridge formation rate was lower in the Ca(OH)2 group than in the other two groups（P＜0. 05), while the incidence of tooth discoloration was lower in the MTA group（P＜0. 05） and higher than in the i RooT group（P＜0. 05). （3） The root canal wall thickness increased in all three groups after treatment compared with that before treatment, and the increase in root canal wall thickness in the Ca(OH)2 group was lower than that in the MTA and i RooT groups after treatment（P＜0. 05). （4） The dental comfort function, fixed function and masticatory function scores were significantly lower in the Ca(OH)2 group than in the MTA and i RooT groups at 6 months postoperatively（P＜0. 05), while the dental esthetics scores were lower in the i RooT group（P＜0. 05） and higher than in the MTA group（P＜0. 05). （5）Serum MMP-3 and IL-8 were lower in all three groups 6 months after surgery than before surgery（P＜0. 05), and the serum MMP-3 and IL-8 levels were higher in the MTA group than in the i RooT group（P＜0. 05） and lower in the CaOH group（P＜0. 05). Conclusion: Both i Root BP Plus and MTA materials have high long-term success rates for vivisection of young permanent teeth, but the MTA material has a high rate of long-term tooth discoloration and thus affects the aesthetics of the teeth. [ABSTRACT FROM AUTHOR]