Exploring multi-omics strategies for herbal treatment of drug-resistant epilepsy:acomprehensive review.

Epilepsy affects approximately 70 million people worldwide. Yet scientists have a partial understanding of the disease pathophysiology due to its heterogenic nature. About 70%of cases of epilepsy are treatable with FDA-approved anti-epileptic drugs while temporal lobeepilepsy with hippocampus sclerosis (TLE-HS) is drug resistant. Numerous herbs have beennoted for their potential anti-convulsant properties. Yet, due to the scarcity of experimental data, there is an urgent need to conduct thorough investigations into these herbs for theirpractical use in treating TLE-HS. In-depth multi-omics research is needed for targetedTLE-HS therapy, focusing on cornu ammonis subregions, dentate gyrus, and also geneticallyglutamate, and γ-aminobutyric acid receptors. Animal models, due to the lack of humanbrain tissue, enable homogeneous sample selection, comparable groups, and ample tissueforin-vitro and ex-vivo studies. Consequently, it becomes feasible to examine the effectivenessof herbs on individual brain regions at the molecular level, paving the way for the potential development of drug interventions to treat TLE-HS. [ABSTRACT FROM AUTHOR]