幽门螺杆菌根除治疗对儿童特发性血小板减少性 紫癜疗效的 meta 分析.

Objective To systematically evaluate the curative effect of Helicobacter pylori (Hp) eradication therapy on idiopathic thrombocytopenic purpura (ITP) in children. Methods The randomized controlled trials of the curative effect of Hp eradication therapy on ITP in children were searched by computer in PubMed, Embase, Cochrane database of randomized controlled trials and Wanfang medical database. The retrieval time was from the establishment of the databases to August 2022. Statistical analyses were performed by using RevMan5.4 software and Stata12.0 software. Results A total of seven randomized controlled trials regarding 315 pediatric patients were included in this study. Compared with immunotherapy alone, Hp eradication therapy combined with immunotherapy could obviously improve the overall remission rate and complete remission rate, and reduce the recurrence rate after treatment (odds ratio=2.87,3.27,0.24,95% confidence interval: 1.60-5.13,2.01-5.32,0.11-0.53,P=0.000 40,＜0.000 01,0.000 30. Conclusion Hp eradication therapy has a beneficial effect on the clinical remission and relapse prevention of ITP in children. However, considering the limited quality of current research evidence, further large-scale and high-quality studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]