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Divergent Synthesis of Isoxazolo[5,4‐b]pyridines.
- Source :
-
European Journal of Organic Chemistry . Mar2024, Vol. 27 Issue 9, p1-6. 6p. - Publication Year :
- 2024
-
Abstract
- Isoxazolopyridines are highly significant for the development of pharmaceuticals and new materials. In continuation of our ongoing research on transformations of 5‐aminoisoxazoles, we report herein a divergent synthesis of two kinds of novel isoxazolo[5,4‐b] pyridines through condensation of 5‐aminoisoxazoles with β,γ‐alkynyl‐α‐imino esters. By using two different silver salts and a phosphoric acid as catalysts, isoxazolo[5,4‐b] pyridine‐α‐carboxylates and isoxazolo[5,4‐b] pyridine‐γ‐carboxylates were constructed as major isomers in moderate to good yields, respectively. The structures of the two kinds of the isoxazolo[5,4‐b] pyridines were confirmed by X‐ray crystal structural analysis. Furthermore, control experiments were conducted to elucidate the reaction mechanism. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SILVER salts
*ACID catalysts
*ISOMERS
*ESTERS
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 27
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 175799408
- Full Text :
- https://doi.org/10.1002/ejoc.202301287