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A new way of identifying viral pathogens reactivating in cellular therapy products.
- Source :
-
Immunology & Cell Biology . Mar2024, Vol. 102 Issue 3, p153-155. 3p. - Publication Year :
- 2024
-
Abstract
- In this article, we discuss a recently published article that demonstrated a novel way of identifying viral pathogens reactivating in human cells to be used as cellular therapy, in this instance chimeric antigen receptor (CAR) T cells. The authors used search engines and databases to identify viruses able to reactivate in T cells and then tested this initially in T‐cell cultures, specifically human herpesvirus 6. This virus was then shown to reactivate infrequently in vitro and in vivo in CAR T cells as a consequence of T‐cell activation. The methodology may be most clinically useful for more frequently reactivating viruses in other types of cellular therapy such as allogenic CAR T cells or induced pluripotent stem cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 102
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 175799332
- Full Text :
- https://doi.org/10.1111/imcb.12724