Nestin drives allergen‐induced airway smooth muscle hyperplasia and airway remodeling.

This article discusses the role of nestin, a protein, in driving airway smooth muscle (ASM) hyperplasia and airway remodeling in asthma. The study found that nestin expression is upregulated in asthmatic ASM cells and tissues. By using mouse models and in vitro experiments, the researchers demonstrated that nestin plays a crucial role in ASM hyperplasia and airway remodeling. The study also suggests that nestin may interact with other proteins, such as 14-3-3 and mTOR, to induce ASM proliferation. These findings provide insights into the mechanisms underlying asthma and may have implications for future therapeutic approaches. [Extracted from the article]