Bioinformatic analysis of human SLC15A3 gene and protein.

Objective: To investigate complete mechanism of SLC15A3 regulation and function. Methods: Human SLC15A3 gene promoter elements and protein structure, physio-chemical and localization properties, and its evolutionary relationships were described by bioinformatics tools. Results: Human SLC15A3 gene was regulated by multiple transcription factors (YY1, AP-1, c-Fos, c-Jun, Sp1 and NF-κB) . SLC15A3 protein was a hydrophobic unstable protein composed of 581 amino acid residues, its highly conserved in mammals, and interacted with proteins such as CD6, TYROBP, CD5 and NOD2. Conclusion: This information from bioinformatics analysis will help future attempts to better understand regulation mechanisms of SLC15A3 in development of inflammatory response. [ABSTRACT FROM AUTHOR]