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Associations between healthy food groups and platelet-activating factor, lipoprotein-associated phospholipase A2 and C-reactive protein: a cross-sectional study.
- Source :
-
European Journal of Nutrition . Mar2024, Vol. 63 Issue 2, p445-460. 16p. - Publication Year :
- 2024
-
Abstract
- Purpose: To investigate the association between pro-inflammatory markers platelet-activating factor (PAF), lipoprotein-associated phospholipase A2 (Lp-PLA2), hsCRP, and intake of core food groups including fruit, cruciferous and other vegetables, grains, meat and poultry, fish and seafood, nuts and legumes, and dairy. Methods: A cross-sectional study was conducted. 100 adults (49 ± 13 years, 31% male) with variable cardiovascular disease risk were recruited. Data were collected in 2021 and 2022. Fasting PAF, Lp-PLA2 activity, hsCRP and usual dietary intake (via a validated food frequency questionnaire) were measured. Intake of foods were converted into serves and classified into food groups. Correlations and multiple regressions were performed with adjustment for confounders. Results: A one-serve increase in cruciferous vegetables per day was associated with 20–24% lower PAF levels. An increase of one serve per day of nuts and legumes was associated with 40% lower hsCRP levels. There were small correlations with PAF and Lp-PLA2 and cheese, however, these were not significant at the Bonferroni-adjusted P < 0.005 level. Conclusion: The lack of associations between PAF and Lp-PLA2 and other healthy foods may be due to confounding by COVID-19 infection and vaccination programs which prevents any firm conclusion on the relationship between PAF, Lp-PLA2 and food groups. Future research should aim to examine the relationship with these novel markers and healthy food groups in a non-pandemic setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- *C-reactive protein
*BIOMARKERS
*CARDIOVASCULAR diseases risk factors
*STATISTICS
*LEGUMES
*COVID-19
*IMMUNIZATION
*FOOD consumption
*PHOSPHOLIPASES
*CROSS-sectional method
*MULTIPLE regression analysis
*COVID-19 vaccines
*NUTRITIONAL requirements
*MEDICAL protocols
*QUESTIONNAIRES
*NATURAL foods
*BLOOD coagulation factors
*WHITE people
*BRASSICACEAE
*DATA analysis
*NUTS
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 63
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 175695769
- Full Text :
- https://doi.org/10.1007/s00394-023-03277-8