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Risk Factor Analysis for Developing Major Complications Following Esophageal Surgery—A Two-Center Study.

Authors :
Stüben, Björn-Ole
Plitzko, Gabriel Andreas
Stern, Louisa
Schmeding, Rainer
Karstens, Karl-Frederick
Reeh, Matthias
Treckmann, Jürgen Walter
Izbicki, Jakob Robert
Saner, Fuat Hakan
Neuhaus, Jan Peter
Tachezy, Michael
Hoyer, Dieter Paul
Source :
Journal of Clinical Medicine. Feb2024, Vol. 13 Issue 4, p1137. 10p.
Publication Year :
2024

Abstract

Background: Esophagectomy carries a high risk of morbidity and mortality compared to other major surgeries. With the aim of creating an easy-to-use clinical preoperative risk assessment tool and to validate previously described risk factors for major complications following surgery, esophagectomies at two tertiary medical centers were analyzed. Methods: A total of 450 patients who underwent esophagectomy for esophageal carcinoma at the University Medical Centre, Hamburg, or at the Medical Center University Duisburg-Essen, Germany (January 2008 to January 2020) were retrospectively analyzed. Epidemiological and perioperative data were analyzed to identify the risk factors that impact major complication rates. The primary endpoint of this study was to determine the incidence of major complications. Results: The mean age of the patients was 63 years with a bimodal distribution. There was a male predominance across the cohort (81% vs. 19%, respectively). Alcohol abuse (p = 0.0341), chronic obstructive pulmonary disease (p = 0.0264), and cardiac comorbidity (p = 0.0367) were associated with a significantly higher risk of major complications in the multivariate analysis. Neoadjuvant chemotherapy significantly reduced the risk of major postoperative complications (p < 0.0001). Conclusions: Various patient-related risk factors increased the rate of major complications following esophagectomy. Patient-tailored prehabilitation programs before esophagectomy that focus on minimizing these risk factors may lead to better surgical outcomes and should be analyzed in further studies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
13
Issue :
4
Database :
Academic Search Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
175669167
Full Text :
https://doi.org/10.3390/jcm13041137