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The Impact of Genetics on Cognition: Insights into Cognitive Disorders and Single Nucleotide Polymorphisms.

Authors :
Spoto, Giulia
Di Rosa, Gabriella
Nicotera, Antonio Gennaro
Source :
Journal of Personalized Medicine. Feb2024, Vol. 14 Issue 2, p156. 8p.
Publication Year :
2024

Abstract

This article explores the complex relationship between genetics and cognition, specifically examining the impact of genetic variants, particularly single nucleotide polymorphisms (SNPs), on cognitive functions and the development of neuropsychiatric disorders. Focusing on neurotransmitter regulation within the prefrontal cortex's dopaminergic circuits, this study emphasizes the role of genes like COMT, PRODH, and DRD in shaping executive functions and influencing conditions such as ADHD and schizophrenia. Additionally, it explores the significance of genetic factors in neurodevelopmental disorders, emphasizing the need for early identification to guide appropriate therapeutic interventions. This article also investigates polymorphisms in the transsulfuration pathway, revealing their association with cognitive impairment diseases. Computational analyses, including machine learning algorithms, are highlighted for their potential in predicting symptom severity in ADHD based on genetic variations. In conclusion, this article underscores the intricate interplay of genetic and environmental factors in shaping cognitive outcomes, providing valuable insights for tailored treatments and a more comprehensive understanding of neuropsychiatric conditions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20754426
Volume :
14
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Personalized Medicine
Publication Type :
Academic Journal
Accession number :
175668639
Full Text :
https://doi.org/10.3390/jpm14020156