Effect of prolonged use of Aromatase inhibitor Letrozole on increasing the risk of cardiovascular accidents in pre-menopausal women.

Introduction: Uterine myomas are very common benign tumours of the uterus. The patients may not be willing or may not be fit for surgical procedures. Medical management is done in a few cases. The perimenopausal age group is high risk for cardiovascular accidents. Hence, the side effects of the medical management should be considered. Material and Methods: The study was done in 30 perimenopausal patients with uterine myomas. 2.5 mg of Letrozole (Aromatase Inhibitor) was given for 3 months. The hormonal profile and lipid profile was done to know about the risk of increasing cardiovascular accidents in these patients. Results: Letrozole when used for 3 months did not change the hormonal profile and lipid profile of the patients. [ABSTRACT FROM AUTHOR]