Novel synthetic routes for Pyrimidine, Pyridine and Pyrazole Derivatives and Their Antibacterial Evaluation.

An efficient and facile protocol for the synthesis of pyrimidine, pyridine and pyrazole ring systems was reported, Reaction of isothiocyanate with enaminone to give pyrimidinthione 4, the reactions of pyrimidinthione 4 with several active species such as ethyliodide, benzaldehyde, p-anisidine, acetylacetone were studied, the reactions of isothiocyanate 1 with active species such as ethyl cyanoacetate to form thioamide then oxazine, thiourea togivethiosemicarbazide, hydrazine, and phenylhydrazine resulted in pyrimidines. Novel compounds were tested for biological activity against Gram+ bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram– bacteria (E. Coli and Klebsiella pneumonia) using Gentamycin as reference standard drug, Results showed novel compounds as potent antibacterial agents against all bacterial strains except (Klebsiella pneumonia bacteria). [ABSTRACT FROM AUTHOR]