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A new T cell subset expressing B220 and CD4 in lpr mice: defects in the response to mitogens and in the production of IL-2.
- Source :
-
Clinical & Experimental Immunology . Oct1988, Vol. 74 Issue 1, p36-40. 5p. - Publication Year :
- 1988
-
Abstract
- Autoimmune-prone mice homozygous for the 1pr gene develop prominent lymphadenopathy composed mainly of Thy-1+ CD8- CD4- B220+ cells. Expression patterns of B220vsCD4 on lymph node cells from 1pr mice were analysed using two-colour flow microfluorometry. B220+CD4+ cells, which were hardly seen in lymph nodes of B6-+ / + mice, increased significantly in B6-lpr mice with ageing. Functional analysis of purified B220+ CD4+ cells from 1pr mice revealed that these cells scarcely responded to T cell mitogens with or without rIL-2. Furthermore, B220+ CD4+ cells were defective in IL-2 production when cultured with Con A. On the other hand, B220-CD4+ cells from B6-lpr mice showed an ability to respond to T cell mitogens similar to that of B220- CD4+ cells from B6-+/+ mice. These results indicate that an unusual T cell subset expressing both B220 and CD4 in 1pr mice is functionally defective, but the intrinsic ability of B220- CD4+ cells is almost intact as compared with the counterpart in normal mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*LYMPHOCYTES
*LYMPH nodes
*MITOGENS
*LECTINS
*AGING
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 74
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 17562010