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On Demand Synthesis of C3−N1' Bisindoles by a Formal Umpolung Strategy: First Total Synthesis of (±)‐Rivularin A.

Authors :
Tokushige, Keisuke
Abe, Takumi
Source :
Chemistry - A European Journal. Feb2024, Vol. 30 Issue 11, p1-5. 5p.
Publication Year :
2024

Abstract

In this work, a straightforward synthesis of C3−N1' bisindolines is achieved by a formal umpolung strategy. The protocols were tolerant of a wide variety of substituents on the indole and indoline ring. In addition, the C3−N1' bisindolines could be converted to C3−N1' indole‐indolines and C3−N1'‐bisindoles. Also, we have successfully synthesized (±)‐rivularin A through a biomimetic late‐stage tribromination as a key step. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09476539
Volume :
30
Issue :
11
Database :
Academic Search Index
Journal :
Chemistry - A European Journal
Publication Type :
Academic Journal
Accession number :
175605616
Full Text :
https://doi.org/10.1002/chem.202302963