One step cleanup of 160 pesticides and veterinary drugs in aquatic products using melamine-based automatic pressure filtration purification method combined with HPLC-MS/MS.

[Display omitted] • A multi-channel pressure filtration purification method was developed and able to purify up to 15 samples per run. • A unique adsorbent of melamine sponge was selected for rapid and effective purification of drug residues in aquatic products. • A rapid high throughput method was proposed for quantification of 160 pesticide and veterinary drug residues in aquatic products. • A health risk assessment was conducted on pesticides and veterinary drug residues in aquatic products. A 15-channel pressure filtration purification method was presented for high throughput sample preparation of aquatic products. A cost-effective device was constructed and melamine sponge was selected as the cleanup sorbent. Upon interfacing with HPLC-MS/MS, the analytical procedure demonstrated its suitability for quantifying 160 pesticides and veterinary drug residues in aquatic products such as fish, shrimp, and crab. The method achieved sample recoveries ranging from 61.3 to 124.9 %. The detection limits were established between 0.5 and 1.0 μg/kg, while the quantitation limits were confirmed to be within the range of 1.0–2.0 μg/kg. The method was applied to quantify the pesticide and veterinary drug residues in mostly consumed aquatic products from five coastal provinces in China. The results showed significant differences between different aquatic products in the concentrations of pesticide and veterinary drug residues, implying the necessity of supervision for the accurate determination of pesticides and veterinary drugs. [ABSTRACT FROM AUTHOR]