α-Tocopherol Mitigates Adverse Effects of Potassium Bromate on Hematological Parameters and Markers of Hepatic Function in Rat Model.

Introduction: α-tocopherol is an antioxidant which protects tissues from oxidative stress via inhibition of free radicals production and lipid peroxidation after exposure to tissue toxicants. The potassium bromate is a food additive which causes toxic effects on tissues through generation of reactive oxygen species and impairment of antioxidant system. The current study was aimed to assess the mitigating activity of α-tocopherol on adverse effects of potassium bromate on haematological parameters and hepatic function markers in rats. Materials and Methods: Twenty Wistar rats were equally grouped into four (1-4) and respectively administered with distilled water, α-tocopherol (50mg/kg), potassium bromate (25mg/kg) and α-tocopherol (50mg/kg) + potassium bromate (25mg/kg) for twenty eight days. Blood sample of study animals was collected and employed for haematological and hepatic fucntion analysis. Results: The findings of this study showed that exposure to potassium bromate causes adverse effect on haematological parameters (erythrocyte count, haematocrit, haemoglobin, platelet count, neutrophil count, leucocyte count, lymphocyte count and monocyte count) and markers of hepatic function (ALP, ALT and AST) in the study animals. However, co-treatment with α-tocopherol showed significant mitiagtion on the adverse effect of the potassium bromate exposure. Conclusion: The potency of α-tocopherol as an antioxidant demonstrated its efficacy in mitigating the adverse effects of potassium bromate on haematological parameters and markers of hepatic tissue function. Hence, α-tocopherol may provide a possible solution to tissue toxicities mediated by exposure to potassium bromate. [ABSTRACT FROM AUTHOR]