COMPUTATIONAL MODELING OF A LAYERED AORTIC MEDIAL WALL CONSIDERING EFFECTIVE RESIDUAL STRESSES.

We previously developed a simplified finite element (FE) "unit" model to reproduce the mechanical interaction between the smooth muscle layer and elastic lamina (EL) in the aortic media. Nevertheless, whether this simplified FE model can represent the structure of a real medial wall and whether its modeling technique can help in developing a highly sophisticated and structure-based aortic FE model should be determined. Therefore, this study aimed to computationally represent EL buckling in the aortic medial ring at an unloaded state based on the integrated unit models and reproduce transmural variations in EL waviness across the vascular wall. We confirmed that the inner and outer layers of the medial wall were relatively subjected to compressive and tensile residual stresses, respectively, at the unloaded state, implying that the ring model will open spontaneously when it is radially cut. In addition, the residual stresses computed under such a stress-free condition were comparable to the analytically estimated values, partially supporting the validity of our modeling approach. Although further study is still required, the information obtained in this study will greatly improve the understanding of basic aortic physiology and pathophysiology and provide a basis for performing more sophisticated computational modeling of the aortic wall. [ABSTRACT FROM AUTHOR]