Back to Search
Start Over
Cell-free DNA Screening for Aneuploidy.
- Source :
-
Clinical Obstetrics & Gynecology . Sep2023, Vol. 66 Issue 3, p557-567. 11p. - Publication Year :
- 2023
-
Abstract
- Cell-free DNA (cfDNA) screening has high detection for the common fetal autosomal aneuploidies, but is not diagnostic. The positive predictive value should be utilized in counseling after a positive cell-free DNA screen, and diagnostic testing should be offered for confirmation. cfDNA screening does not report a result in ~3% of cases; nonreportable results indicate an increased risk for aneuploidy and some adverse perinatal outcomes. False-positive cfDNA screening occurs due to confined placental mosaicism, maternal copy number variants, mosaicism, and cancer. Pretest education and counseling should be provided with emphasis on the potential benefits, risks, and limitations before cfDNA screening. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099201
- Volume :
- 66
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical Obstetrics & Gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 175570901
- Full Text :
- https://doi.org/10.1097/GRF.0000000000000796