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Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study.

Authors :
Madani, Ali Hamidi
Pakdaman, Mohammad
Mokhtari, Gholamreza
Kazemnezhad, Ehsan
Madani, Mohammad Hamidi
Fathollahi, Ali
Herfeh, Nadia Rastjou
Roohinezhad, Roozbeh
Source :
International Journal of Fertility & Sterility. Apr2024, Vol. 18 Issue 2, p167-172. 6p.
Publication Year :
2024

Abstract

Background: Varicocele is one of the most common treatable causes of male infertility, and its treatment may be beneficial for fertility. This study aimed to evaluate fertility rate and DNA fragmentation index (DFI) following varicocelectomy in primary infertile men with clinical varicocele. Materials and Methods: This prospective longitudinal study was conducted on primary infertility men, in a tertiary center from December 2018 to December 2019 with one-year follow-up. Data of the semen parameters, DFI (%), and fertility rate were gathered before, as well as 4 and 12 months after undergoing varicocelectomy. For data analysis, SPSS software and analytical test were used. Results: Out of 76 patients who were analyzed, 22 (29%) became fertile and 54 (71%) remained infertile. Semen parameters and DFI (%) were improved significantly following varicocelectomy (P<0.001). Smoking history, occupational heated exposure, body mass index (BMI), and infertility duration were determined as predictors associated with fertility status (P<0.05). Conclusion: Although varicocele repair improved the DFI, the fertility rate was achieved in less than one-third of patients; it seems that the other parameters, such as the history of smoking, occupational heated exposure, overweight, and duration of infertility should be considered as predictors of fertility status, in primary infertile men who are a candidate for varicocelectomy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2008076X
Volume :
18
Issue :
2
Database :
Academic Search Index
Journal :
International Journal of Fertility & Sterility
Publication Type :
Academic Journal
Accession number :
175494448
Full Text :
https://doi.org/10.22074/IJFS.2023.1990486.1441