沿胸腔引流管接种的皮肤转移性肺腺癌: 1 例报告.

There was a 61-year-old male patient with cutaneous metastatic lung adenocarcinoma inoculated along a thoracic drainage tube treated in Zhongshan Hospital, Fudan University. The duration of disease was over 2 weeks. The skin lesions were extensive and appeared as purplish red nodules ranging in size from mung bean to small walnut. The nodules were tough and solid, smooth in surface, with infiltration while without ulceration, pruritus or tenderness. The patient developed chest tightness and pain without obvious causes, dull pain in nature and less white sputum 6 weeks before the eruption, and then was diagnosed as malignant tumors of the left lung (poorly differentiated adenocarcinoma), cT1cN3M1c stage Ⅳ B (pleura, bone). Gene tests showed that epidermal growth factor receptor(EGFR)21 exon point mutation L858r，Ros1(-), anaplastic lymphoma kinase (ALK)(-), and physical status score (PS) of 0. The treatment was Dactinib 45mg once each day, supplemented the bone preservation therapy by ibandronic acid. As the patient's condition did not significantly improve and skin nodules increased, also the abdominal B-ultrasound examination showed that multiple metastases in liver, the treatment was changed to Ectinib hydrochloride tablets (Kemena) of 125 mg 3 times a day, combined with Crizotinib capsules (Secor) of 200 mg twice a day. Unfortunately, the patient has now been lost to follow-up. [ABSTRACT FROM AUTHOR]