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Preparation of graphene oxide nanoparticles and their derivatives: Evaluation of their antimicrobial and anti-proliferative activity against 3T3 cell line.
- Source :
-
Journal of Dispersion Science & Technology . Mar2024, Vol. 45 Issue 3, p381-389. 9p. - Publication Year :
- 2024
-
Abstract
- Antibacterial applications of graphene derivatives have been very highlighted during the last decade. In this study, graphene-based materials, i.e., graphene oxide (GO), reduced graphene oxide (RGO), and carboxylated graphene oxide (GO-COOH), were synthesized and characterized by UV–vis spectrophotometry, energy dispersive X-ray spectroscopy (EDX), and TEM. The main difference in these nanomaterials is the content of their oxygen-containing functional groups. According to EDX elemental analysis, GO-COOH has the highest ratio of carbon to oxygen and the highest oxygen-containing functional groups. Cytotoxicity of GO, RGO, and GO-COOH in eight concentrations at two times (24 and 48 h) on 3T3 cell lines showed concentration-dependence cytotoxicity for these three nanomaterials. The antimicrobial and antibiofilm properties of these three materials against gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria, as well as a fungus (Candida albicans), were evaluated by MIC, MBC, anti-biofilm, and Time-Kill tests. Our data demonstrated that the GO-COOH has the highest antimicrobial properties, which can result from increasing the oxygen-containing functional groups. To the best of our knowledge, comparing all cytotoxic, antibacterial, antifungal, and anti-biofilm properties of these three graphene derivatives in one study has not been reported yet. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01932691
- Volume :
- 45
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Dispersion Science & Technology
- Publication Type :
- Academic Journal
- Accession number :
- 175415543
- Full Text :
- https://doi.org/10.1080/01932691.2022.2151458