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Association Between Staphylococcus Aureus Colonization and Pediatric Atopic Dermatitis: A Systematic Review and Meta-Analysis.
- Source :
-
Indian Journal of Dermatology . Nov/Dec2023, Vol. 68 Issue 6, p619-627. 10p. - Publication Year :
- 2023
-
Abstract
- Background: Atopic dermatitis is a chronic inflammatory skin condition common in early childhood. Acute exacerbation is frequently associated with Staphylococcus aureus colonization. Aims and Objectives: This study aims to explore the relationship between S. aureus skin and nasal colonization with pediatric atopic dermatitis. Methods: A systematic review and meta-analysis were conducted by comparing atopic dermatitis patients aged ≤18 years and nondiseased controls. A random-effects model was used to obtain the pooled prevalence and odds ratio of S. aureus colonization at eczematous skin, nonlesional skin, and nasal cavity. Subgroup analyses for colonization with methicillin-resistant S. aureus were also evaluated. Results: A total of 2,670 cases and 1,224 controls from 26 studies were included in the meta-analysis. S. aureus colonization at eczematous skin and nasal cavity is significantly higher in atopic dermatitis compared to control with odds ratios of 10.55 (95% confidence interval [CI]; 4.85-22.92, P < .001) and 2.38 (nasal cavity; 95% CI; 1.46-3.90, P < .001), respectively. The pooled prevalence of skin and nasal colonization were 55.0% (eczematous skin; 95% CI; 38.3-71.7), 23.3% (nonlesional skin; 95% CI; 12.6-33.9), and 56.3% (95% CI; 43.2-69.4), respectively. Methicillin-resistant S. aureus strain was obtained from the nares and eczematous skin with rates of 11.6% (95% CI; 6.5-16.7) and 8.5% (95% CI; 4.3-12.8), respectively. Conclusion: Children with atopic dermatitis are more prone to skin and nasal colonization by S. aureus compared to nondiseased individuals. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SKIN microbiology
*HOST-bacteria relationships
*SKIN diseases
*ONLINE information services
*MEDICAL databases
*COMMUNICABLE diseases
*META-analysis
*CONFIDENCE intervals
*MEDICAL information storage & retrieval systems
*SYSTEMATIC reviews
*METHICILLIN-resistant staphylococcus aureus
*NASAL cavity
*STAPHYLOCOCCAL diseases
*RISK assessment
*ATOPIC dermatitis
*DESCRIPTIVE statistics
*ODDS ratio
*MEDLINE
*DISEASE risk factors
*DISEASE complications
*ADOLESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 00195154
- Volume :
- 68
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 175397409
- Full Text :
- https://doi.org/10.4103/ijd.ijd_453_22