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Palladium‐Catalyzed Carbonylative Multicomponent Fluoroalkylation of 1,3‐Enynes: Concise Construction of Diverse Cyclic Compounds.
- Source :
-
Angewandte Chemie International Edition . 2/19/2024, Vol. 63 Issue 8, p1-8. 8p. - Publication Year :
- 2024
-
Abstract
- Multicomponent reactions, particularly those entailing four or more reagents, have presented a longstanding challenge due to the inherent complexities associated with balancing reactivity, selectivity, and compatibility. In this study, we describe a palladium‐catalyzed multi‐component fluoroalkylative carbonylation of 1,3‐enynes. A series of products featuring three active functional groups‐allene, fluoroalkyl, and carboxyl, were efficiently and selectively integrated in a single chemical operation. Furthermore, more intricate fluoroalkyl‐substituted pyrimidinones can be constructed by simply altering the 1,3‐bisnucleophilic reagent. This approach also provides a valuable strategy for the late‐stage modification of naturally occurring molecules and concise construction of diverse cyclic compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYCLIC compounds
*CARBONYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 63
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 175387704
- Full Text :
- https://doi.org/10.1002/anie.202318257