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Tumor-targeting bacteria as immune stimulants – the future of cancer immunotherapy?
- Source :
-
Critical Reviews in Microbiology . Feb2024, p1-16. 16p. 2 Illustrations, 1 Chart. - Publication Year :
- 2024
-
Abstract
- AbstractCancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a minority of patients currently achieve durable remissions. In general, responsive patients appear to have either a high number of tumor neoantigens, a preexisting immune cell infiltrate in the tumor microenvironment, or an ‘immune-active’ transcriptional profile, determined in part by the presence of a type I interferon gene signature. These observations suggest that the therapeutic efficacy of immunotherapy can be enhanced through strategies that release tumor neoantigens and/or produce a pro-inflammatory tumor microenvironment. In principle, exogenous tumor-targeting bacteria offer a unique solution for improving responsiveness to immunotherapy. This review discusses how tumor-selective bacterial infection can modulate the immunological microenvironment of the tumor and the potential for combination with cancer immunotherapy strategies to further increase therapeutic efficacy. In addition, we provide a perspective on the clinical translation of replicating bacterial therapies, with a focus on the challenges that must be resolved to ensure a successful outcome. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1040841X
- Database :
- Academic Search Index
- Journal :
- Critical Reviews in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 175382794
- Full Text :
- https://doi.org/10.1080/1040841x.2024.2311653