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IDENTIFICATION AND DIAGNOSIS OF POSSIBLE MUTATIONS IN HUMAN P-53 LYMPHOCYTES.
- Source :
-
Pharmacophore . 2023, Vol. 14 Issue 6, p52-58. 7p. - Publication Year :
- 2023
-
Abstract
- This study looked at a few confirmed cases of chronic lymphocytic leukemia (CLL) that may have had mutations in the human B lymphocyte genome's P-53 gene. The ELISA technique was used to determine the frequency of p-53 protein expression in twenty CLL patients undergoing evaluation in stages II–III / IV. In 17 of the 20 cases, the average amounts of p-53 proteins were found to be 16.76 μg/dl, with a probability index of p = 0.034 and a CV of 0.5%. It was discovered that as the illness progressed, the proportion of p-53 positive isoform proteins rose above normal. The percentage was 15% ± 2 in stages 1-2 and 100% in stages 3-4. Recent studies have shown that the p-53 protein inhibits protein kinase B, the AMPK protein, and the mTOR complex, hence mediating genes that trigger autophagy and stimulating autophagy. One potential use of the p-53 protein's role in cancer cell autophagy is the development of a novel anti-cancer medicinal approach. When a patient develops resistance to the initial line of treatment, the ELISA approach has shown to be an invaluable prognostic tool for CLL, enabling the administration of customized medication. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22295402
- Volume :
- 14
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Pharmacophore
- Publication Type :
- Academic Journal
- Accession number :
- 175350111
- Full Text :
- https://doi.org/10.51847/z8kBl0vAMH