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Four new steroidal glycosides from Lilium lancifolium Thunb. and their antitumor activity.
- Source :
-
Fitoterapia . Mar2024, Vol. 173, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Four new steroidal glycosides (1–4), including two steroidal saponins named lililancifoloside B and C (1 – 2), one pregnane glycoside named lililancifoloside D (3), and one C22-steroidal lactone glycoside named lililancifoloside E (4), together with five known ones (5–9), were isolated from the bulbs of Lilium lancifolium Thunb. By using spectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS, the structures of 1–4 were elucidated. All isolates were tested for their cytotoxic potential against the MCF-7, MDA-MB-231, HepG2, and A549 cell lines. Compound 6 distinguished out among them, IC 50 values of 3.31, 5.23, 1.78, and 1.49 μM against the four cell lines, respectively. Other compounds such as compound 3 , 5 , and 9 have also shown specific cytotoxic activity. Next, studies showed that compound 6 might cause HepG2 cells to undergo a cell cycle arrest during the G2/M phase and apoptosis. [Display omitted] • Four new steroidal glycosides were isolated from the bulbs of Lilium lancifolium Thunb.. • The cytotoxicity of all isolates against MCF-7, MDA-MB-231, HepG2, and A549 cell lines were investigated. • Compound 6 displayed significant cytotoxic activitity against all tested cell lines. • Studies revealed that compound 6 could induce cell cycle arrest at G2/M phase and apoptosis in HepG2 cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 173
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 175343480
- Full Text :
- https://doi.org/10.1016/j.fitote.2023.105808