American College of Toxicology.

This document is a collection of abstracts from the 44th Annual Meeting of the American College of Toxicology, covering a range of topics related to toxicology research. The abstracts discuss various studies, including the protective effect of an antioxidant on kidney fibrosis in mice, sex differences in the lung-brain axis transcriptome in response to exposure to indoor fungi, and the evaluation of respiratory sensitizers using an in vitro model. Other studies explore the role of asparagine synthetase in colorectal cancer tumor metabolism, the induction of platinum resistance in ovarian cancer by certain substances, and the modulation of lung injury and inflammation by an RNA-binding protein. Additionally, the frequency of potential drug interactions in pediatric patients and the rescue role of myricetin in testicular oxidative stress, inflammation, and apoptosis in a rat model of Parkinson's disease are examined. The document also includes studies on the effects of nicotine products on gingival tissue, the safety evaluation of a novel sweetener alternative, the cardiovascular effects of a specific drug in monkeys, the use of an in silico system for drug development assessments, the release of cardiac troponin I from cardiomyocytes, the Membrane Proteome Array platform for assessing biotherapeutics, the translational and in silico assessment of liver injury for a specific compound, a modified method for collecting cerebrospinal fluid in rodents and monkeys, and different methods of delivering gene therapies to the central nervous system in non-human primates. These abstracts provide [Extracted from the article]