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Risk assessment—based verification of the CertiPUR TM limit values for toluene diamine and methylene dianiline in flexible polyurethane foam.
- Source :
-
Toxicology & Industrial Health . Mar2024, Vol. 40 Issue 3, p104-116. 13p. - Publication Year :
- 2024
-
Abstract
- Flexible polyurethane foams (PUF) are used in many consumer products. PUF may contain trace levels of aromatic diamine impurities that could represent a potential health risk. The risk associated with sleeping on a PUF mattress was evaluated. Toxicity benchmarks for sensitization and non-cancer endpoints were derived from the respective points-of-departure using standard assessment factors. For the cancer endpoints, toxicity benchmarks were derived from the 25th-percentile values of animal studies. Recently published emission and migration data allowed to link exposure with the CertiPURTM voluntary quality limits of ≤5 mg.kg−1 for 2,4-toluene diamine and 4,4'-methylene dianiline in PUF. Using conservative exposure scenarios, lifetime-average daily internal doses from the combined inhalation and dermal exposures were calculated. Margins of safety for non-cancer and sensitization endpoints were >104. The theoretical excess cancer risk was ≤1.5 × 10−7. It is concluded that sleeping on a mattress that satisfies the CertiPUR limit value does not pose undue risk to consumers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07482337
- Volume :
- 40
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Toxicology & Industrial Health
- Publication Type :
- Academic Journal
- Accession number :
- 175326334
- Full Text :
- https://doi.org/10.1177/07482337231224514