Severe primary hypothyroidism-related hyperprolactinemia and secondary amenorrhea.

We aim to present an adult female confirmed with severe hypothyroidism due to Hashimoto's autoimmune thyroiditis that was associated with hyperprolactinemia which, combined, led to secondary amenorrhea. Additionally, hypercholesterolemia, anemia and vitamin D deficiency were confirmed, and the patient's electrocardiogram showed flattened T waves. The value of TSH (thyroid stimulating hormone) was unexpectedly high, approximately 100 times upper the normal limit. The patient experienced a progression of clinical manifestations within one year, while she did not seek for medical care. This unexpected severity of thyroid hormones deficiency is rarely found nowadays due to active screening protocols and easy access to thyroid assessment; however, in young individuals, the clinical tolerance to myxedema-associated issues is higher than seen in seniors, thus a delay of diagnosis might be found. Whether this impacts the overall reproductive potential in young females mostly depends on the compliance to lifelong hormonal replacement and surveillance of adequate serum hormonal levels, including during pregnancy. [ABSTRACT FROM AUTHOR]