华山版听觉词语学习测验在主观认知下降和 轻度认知障碍患者中的应用初探.

Objective：To explore the diagnostic value of auditory verbal learning test-Huashan version (AVLT-H)of memory impairment in patients with subjective cognitive decline (SCD)and mild cognitive impairment (MCI). Method：According to the inclusion criteria, the recruited elderly were screened and divided into three groups: normal cognition (NC), SCD and MCI group. The neuropsychological tests including mini-mental state examination (MMSE), Montreal cognitive assessment-Beijing version (MOCA-BJ) and AVLT-H were completed after inclusion. The scores of MMSE, MoCA-B, AVLT-N2, N3, N4, N5, N6 and N7 were recorded and analyzed. Result：There were significant differences in the scores of MMSE, MoCA and AVLT-H among the three groups (P<0.0167). The adjusted Bonferroni test was used to detect significant differences in post- hoc comparison. There were significant difference in MMSE and MoCA scores between SCD and NC (P<0.001) and between MCI and NC (P<0.001). However, no significant difference between MCI and SCD was found. There were significant difference in N1 score between MCI and NC (P=0.013) and between MCI and SCD (P=0.001), but there was no significant difference between SCD and NC. There were significant difference in AVLT-N2, N3, N4, N5, N6 and N7 scores between MCI and NC (P<0.001) and between MCI and SCD (P<0.001), but there was no significant difference between SCD and NC. The area under the curve of MMSE, MoCA and AVLT-H scores were examined using NC group and SCD group as state variables, respectively. For differentiating MCI and SCD, eAVLT-H scores had a larger area under the curve with higher sensitivity and specificity, N1 and N7 had the highest sensitivity. For distinguishing MCI from NC, AVLT-H and MoCA scores had a larger area under the curve with higher sensitivity and specificity, N4, N6 and N7 had the highest sensitivity. Conclusion：AVLT- H, combined with MMSE and MoCA, can improve the defining diagnostic sensitivity of MCI and SCD from normal cognition. It is recommended to routinely use AVLT-H in a routine assessment for MCI and SCD patients. [ABSTRACT FROM AUTHOR]