Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas.

This article provides an evidence-based review of the clinical outcomes of carbon ion radiotherapy (CIRT) for skull-base chordomas and chondrosarcomas. The authors conducted a systematic literature review and identified 24 studies for review. They found that while surgery remains the primary treatment, CIRT can be considered as an option for patients with unresectable or subtotally removed tumors, high volume residual disease, recurrent disease following surgery or irradiation, and tumors not encroaching on the brainstem or optic apparatus. The authors emphasize the need for ongoing research to further refine the benefits and patient selection for CIRT compared to other forms of radiotherapy. [Extracted from the article]