Advances in Non-Enzymatic electrochemical materials for H2O2 sensing.

[Display omitted] Hydrogen peroxide (H 2 O 2) is produced through the single electron reduction of oxygen in organisms, playing a crucial role in cell signaling and maintaining internal stability. Exploring a simple yet effective method for real-time and quantitative detection of H 2 O 2 in living cells and actual samples holds immense significance. The use of nanocatalysts as sensing materials in the electrochemical detection method has garnered significant attention due to its operational simplicity, high sensitivity, cost-effectiveness, and easy miniaturization. This paper focuses on summarizing contemporary techniques for H 2 O 2 detection, particularly emphasizing electrochemical methods, and highlights significant advancements in electrochemical detection of H 2 O 2 nanomaterials, providing insights into future developments. • Introducing the current methodologies for H 2 O 2 detecting. • Providing a comprehensive overview of non-enzyme nanocatalysts designed for electrochemical H 2 O 2 detection. • Exploring the prospects in the realm of electrochemical detection using non-enzyme catalysts. With the progression of society, an increasing emphasis on physical well-being and environmental safety has driven extensive research into technologies closely aligned with human health and environmental protection. Hydrogen peroxide (H 2 O 2), a representative reactive oxygen species (ROS), serves as one of the products resulting from the single electron reduction of oxygen in organisms, playing a crucial role in cell signaling and maintaining internal stability. Relevant alterations of H 2 O 2 concentrations have been implicated in the pathogenesis of various diseases, including diabetes and cancer. Moreover, the utilization of H 2 O 2 is widely prevalent in various industries including chemical, pharmaceutical, and food sectors. However, the repetitive or uncontrolled utilization of H 2 O 2 engenders deleterious implications for human well-being and environmental integrity. Therefore, there is immense significance in exploring a simple yet effective method for real-time and quantitative detection of H 2 O 2 in living cells and actual samples. The use of nanocatalysts as sensing materials in the electrochemical detection method has garnered significant attention from researchers due to their operational simplicity, high sensitivity, cost-effectiveness, and facile miniaturization. However, there remains a dearth of comprehensive reviews on the electrochemical detection of H 2 O 2 utilizing nanomaterials. In this paper, we focus on summarizing contemporary techniques for H 2 O 2 detection with a specific emphasis on electrochemical detection methods, and highlighting the significant advancements in the field of electrochemical detection of H 2 O 2 nanomaterials while also providing insights into future developments. [ABSTRACT FROM AUTHOR]