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Costal Chondrocyte–Derived Pellet-Type Autologous Chondrocyte Implantation Versus Microfracture for the Treatment of Articular Cartilage Defects: A 5-Year Follow-up of a Prospective Randomized Trial.
- Source :
-
American Journal of Sports Medicine . Feb2024, Vol. 52 Issue 2, p362-367. 6p. - Publication Year :
- 2024
-
Abstract
- Background: Costal chondrocyte–derived pellet-type autologous chondrocyte implantation (CCP-ACI) has been introduced as a new therapeutic option for the treatment of articular cartilage defects. We had previously conducted a randomized controlled trial comparing CCP-ACI versus microfracture at 1 year postoperatively. Purpose: To compare the efficacy and safety of CCP-ACI versus microfracture for the treatment of articular cartilage defects of the knee at 5 years postoperatively. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: This study describes the mean 5-year follow-up of a previously published prospective clinical trial. The previous prospective trial compared the results of CCP-ACI versus microfracture until 1 year of follow-up. Of the 30 patients who were included in the previous study, 25 were followed up for 5 years. Patients were evaluated based on clinical outcome scores (Lysholm score, International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score [KOOS], and visual analog scale for pain), magnetic resonance imaging findings, and rates of treatment failure at last follow-up. Results: The MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) score in the CCP-ACI group was significantly higher than that in the microfracture group at 5 years (62.3 vs 26.7, respectively; P <.0001). The Lysholm score and KOOS score in the CCP-ACI group were significantly higher than those in the microfracture group at 5 years (84.5 vs 64.9, respectively, and 390.9 vs 303.0, respectively; P =.023 and P =.017, respectively). There was 1 case of treatment failure that occurred in the microfracture group. Conclusion: The present randomized controlled trial indicated that the results of both procedures clinically and statistically significantly improved at 1 and 5 years' follow-up in treating cartilage defects, but the results of CCP-ACI were superior to those of microfracture. Magnetic resonance imaging conducted at 1 year and 5 years after CCP-ACI revealed statistically significant superior structural integration with native cartilage tissue compared with microfracture. Registration: NCT03545269 (ClinicalTrials.gov) [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARTILAGE cell transplantation
*RESEARCH
*ACADEMIC medical centers
*CONFIDENCE intervals
*ARTHROPLASTY
*MAGNETIC resonance imaging
*MANN Whitney U Test
*TREATMENT effectiveness
*RANDOMIZED controlled trials
*COMPARATIVE studies
*TREATMENT failure
*T-test (Statistics)
*RESEARCH funding
*QUESTIONNAIRES
*DESCRIPTIVE statistics
*ARTICULAR cartilage injuries
*ARTICULAR cartilage
*STATISTICAL sampling
*LOGISTIC regression analysis
*STATISTICAL correlation
*PATIENT safety
*CELL transplantation
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 03635465
- Volume :
- 52
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- American Journal of Sports Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 175231662
- Full Text :
- https://doi.org/10.1177/03635465231222797